Research Publications

A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis

Kulkarni P, Dasgupta P, Hashimoto Y, Shiina M, Shahryari V, Tabatabai ZL, Yamamura S, Tanaka Y, Saini S, Dahiya R, Majid

Cancer Res. 2021 Mar 15;81(6):1500-1512. doi: 10.1158/0008-5472.CAN-20-0832. Epub 2021 Jan 26.PMID: 33500248.

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Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans

Shiina M, Hashimoto Y, Kulkarni P, Dasgupta P, Shahryari V, Yamamura S, Tanaka Y, Dahiya R.

BMC Cancer. 2021 Sep 15;21(1):1028. doi: 10.1186/s12885-021-08723-6.PMID: 34525952 Free PMC article.

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Suppressor effect of catechol-O-methyltransferase gene in prostate cancer

Hashimoto Y, Shiina M, Maekawa S, Kato T, Shahryari V, Kulkarni P, Dasgupta P, Yamamura S, Saini S, Tabatabai ZL, Dahiya R, Tanaka Y.

PLoS One. 2021 Sep 29;16(9):e0253877. doi: 10.1371/journal.pone.0253877. eCollection 2021. PMID: 34587154 Free PMC article. 

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Role of the PI3K/Akt pathway in cadmium induced malignant transformation of normal prostate epithelial cells

Kulkarni P, Dasgupta P, Bhat NS, Hashimoto Y, Saini S, Shahryari V, Yamamura S, Shiina M, Tanaka Y, Dahiya R, Majid S.

T oxicol Appl Pharmacol. 2020 Dec 15;409:115308. doi: 10.1016/j.taap.2020.115308. Epub 2020 Oct 29.PMID: 33129824

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LncRNA CDKN2B-AS1/miR-141/cyclin D network regulates tumor progression and metastasis of renal cell carcinoma

Dasgupta P, Kulkarni P, Majid S, Hashimoto Y, Shiina M, Shahryari V, Bhat NS, Tabatabai L, Yamamura S, Saini S, Tanaka Y, Dahiya R.

Cell Death Dis. 2020 Aug 19;11(8):660. doi: 10.1038/s41419-020-02877-0.PMID: 32814766 Free PMC article.

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MicroRNA determinants of neuroendocrine differentiation in metastatic castration-resistant prostate cancer

Bhagirath D, Liston M, Patel N, Akoto T, Lui B, Yang TL, To DM, Majid S, Dahiya R, Tabatabai ZL, Saini S.

Oncogene. 2020 Dec;39(49):7209-7223. doi: 10.1038/s41388-020-01493-8. Epub 2020 Oct 9.PMID: 33037409 Free PMC article.

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The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner

Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF. 

Oncotarget. 2019 Feb 19;10(15):1491-1506. doi: 10.18632/oncotarget.26673. eCollection 2019 Feb 19.PMID: 30863497 Free PMC article. 

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Role of a novel race-related tumor suppressor microRNA located in frequently deleted chromosomal locus 8p21 in prostate cancer progression

Bhagirath D, Yang TL, Tabatabai ZL, Shahryari V, Majid S, Dahiya R, Tanaka Y, Saini S.

Carcinogenesis. 2019 Jul 4;40(5):633-642. doi: 10.1093/carcin/bgz058.PMID:  30874288 Free PMC article.

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BRN4 Is a Novel Driver of Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer and Is Selectively Released in Extracellular Vesicles with BRN2

Bhagirath D, Yang TL, Tabatabai ZL, Majid S, Dahiya R, Tanaka Y, Saini S.

Clin Cancer Res. 2019 Nov 1;25(21):6532-6545. doi: 10.1158/1078-0432.CCR-19-0498. Epub 2019 Aug 1.PMID: 31371344 Free PMC article. 

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microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer

Bhagirath D, Yang TL, Bucay N, Sekhon K, Majid S, Shahryari V, Dahiya R, Tanaka Y, Saini S.

Cancer Res. 2018 Apr 1;78(7):1833-1844. doi: 10.1158/0008-5472.CAN-17-2069. Epub 2018 Feb 1.PMID: 29437039 Free PMC article. 

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MicroRNAs as Regulators of Prostate Cancer Metastasis

Dasgupta P, Kulkarni P, Majid S, Hashimoto Y, Shiina M, Shahryari V, Bhat NS, Tabatabai L, Yamamura S, Saini S, Tanaka Y, Dahiya R.

Cell Death Dis. 2020 Aug 19;11(8):660. doi: 10.1038/s41419-020-02877-0.PMID: 32814766 Free PMC article.

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Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression

Kulkarni P, Dasgupta P, Bhat NS, Shahryari V, Shiina M, Hashimoto Y, Majid S, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. 

Mol Cancer Res. 2018 Nov;16(11):1750-1760. doi: 10.1158/1541-7786.MCR-17-0762. Epub 2018 Jul 23.PMID: 30037856 Free PMC article.

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MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma

Dasgupta P, Kulkarni P, Majid S, Shahryari V, Hashimoto Y, Bhat NS, Shiina M, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R.

Mol Cancer Ther. 2018 May;17(5):1061-1069. doi: 10.1158/1535-7163.MCT-17-0925. Epub 2018 Feb 13.PMID: 29440295 Free PMC article.

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Pharmacogenetics-based area-under-curve model can predict efficacy and adverse events from axitinib in individual patients with advanced renal cell carcinoma

Yamamoto Y, Tsunedomi R, Fujita Y, Otori T, Ohba M, Kawai Y, Hirata H, Matsumoto H, Haginaka J, Suzuki S, Dahiya R, Hamamoto Y, Matsuyama K, Hazama S, Nagano H, Matsuyama H.

Oncotarget. 2018 Mar 30;9(24):17160-17170. doi: 10.18632/oncotarget.24715. eCollection 2018 Mar 30.PMID: 29682213 Free PMC article. 

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Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer

Kato T, Hashimoto Y, Wong RK, Mitsui Y, Maekawa S, Chang I, Shahryari V, Yamamura S, Majid S, Saini S, Tabatabai ZL, Dahiya R, Deguchi T, Tanaka Y.

J Cell Mol Med. 2018 Oct;22(10):4676-4687. doi: 10.1111/jcmm.13696. Epub 2018 Aug 22.PMID: 30133114 Free PMC article. 

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A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition

Bucay N, Bhagirath D, Sekhon K, Yang T, Fukuhara S, Majid S, Shahryari V, Tabatabai Z, Greene KL, Hashimoto Y, Shiina M, Yamamura S, Tanaka Y, Deng G, Dahiya R, Saini S.

Cell Death Differ. 2017 Jul;24(7):1263-1274. doi: 10.1038/cdd.2017.69. Epub 2017 May 12.PMID: 28498363 Free PMC article. 

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MicroRNA-720 Regulates E-cadherin-αE-catenin Complex and Promotes Renal Cell Carcinoma

Bhat NS, Colden M, Dar AA, Saini S, Arora P, Shahryari V, Yamamura S, Tanaka Y, Kato T, Majid S, Dahiya R.

Mol Cancer Ther. 2017 Dec;16(12):2840-2848. doi: 10.1158/1535-7163.MCT-17-0400. Epub 2017 Aug 11.PMID: 28802251 Free PMC article.

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The role of miR-24 as a race related genetic factor in prostate cancer

Hashimoto Y, Shiina M, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Shahryari V, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Deng G, Tabatabai L, Kumar D, Dahiya R.

Oncotarget. 2017 Mar 7;8(10):16581-16593. doi: 10.18632/oncotarget.15016. PMID: 28157714 Free PMC article.

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MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer

Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S.

Oncogene. 2017 May 11;36(19):2667-2679. doi: 10.1038/onc.2016.419. Epub 2016 Nov 28.PMID: 27893706 Free PMC article. 

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Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N, Dahiya R. 

Cancer Res. 2015 Apr 1;75(7):1322-31. doi: 10.1158/0008-5472.CAN-14-2931. Epub 2015 Jan 19.PMID: 25600645 Free PMC article.

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CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.

Mitsui Y, Chang I, Fukuhara S, Hiraki M, Arichi N, Yasumoto H, Hirata H, Yamamura S, Shahryari V, Deng G, Wong DK, Majid S, Shiina H, Dahiya R, Tanaka Y.

BMC Cancer. 2015 Dec 1;15:942. doi: 10.1186/s12885-015-1951-0.PMID: 26626260 Free PMC article.
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Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells

Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V, Chang I, Tanaka Y, Enokida H, Nakagawa M, Dahiya R, Yamamura S.
J Biol Chem. 2014 May 2;289(18):12550-65. doi: 10.1074/jbc.M113.488593. Epub 2014 Mar 10.PMID: 24616104 Free PMC article.
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Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N, Dahiya R. 

Cancer Res. 2015 Apr 1;75(7):1322-31. doi: 10.1158/0008-5472.CAN-14-2931. Epub 2015 Jan 19.PMID: 25600645 Free PMC article.

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CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma.

Mitsui Y, Chang I, Fukuhara S, Hiraki M, Arichi N, Yasumoto H, Hirata H, Yamamura S, Shahryari V, Deng G, Wong DK, Majid S, Shiina H, Dahiya R, Tanaka Y.

BMC Cancer. 2015 Dec 1;15:942. doi: 10.1186/s12885-015-1951-0.PMID: 26626260 Free PMC article.
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Upregulation of miR-130b Contributes to Risk of Poor Prognosis and Racial Disparity in African-American Prostate Cancer

Hashimoto Y, Shiina M, Dasgupta P, Kulkarni P, Kato T, Wong RK, Tanaka Y, Shahryari V, Maekawa S, Yamamura S, Saini S, Deng G, Tabatabai ZL, Majid S, Dahiya R.

Cancer Prev Res (Phila). 2019 Sep;12(9):585-598. doi: 10.1158/1940-6207.CAPR-18-0509. Epub 2019 Jul 2.PMID: 31266828 Free PMC article.

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Extracellular miR-224 as a prognostic marker for clear cell renal cell carcinoma

Fujii N, Hirata H, Ueno K, Mori J, Oka S, Shimizu K, Kawai Y, Inoue R, Yamamoto Y, Matsumoto H, Shimabukuro T, Udoh K, Hoshii Y, Dahiya R, Matsuyama H.

Oncotarget. 2017 Nov 15;8(66):109877-109888. doi: 10.18632/oncotarget.22436. eCollection 2017 Dec 15.PMID: 29299115 Free PMC article. 

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MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer

Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S.

Oncogene. 2017 May 11;36(19):2667-2679. doi: 10.1038/onc.2016.419. Epub 2016 Nov 28.PMID: 27893706 Free PMC article. 

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Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma

Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y.

Mol Cancer Res. 2017 Jul;15(7):884-895. doi: 10.1158/1541-7786.MCR-16-0444. Epub 2017 Feb 27.PMID: 28242813 Free PMC article. 

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PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma

Yoshino H, Nohata N, Miyamoto K, Yonemori M, Sakaguchi T, Sugita S, Itesako T, Kofuji S, Nakagawa M, Dahiya R, Enokida H.

Cancer Res. 2017 Nov 15;77(22):6321-6329. doi: 10.1158/0008-5472.CAN-17-1589. Epub 2017 Sep 26.PMID: 28951458 Free PMC article. 

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MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2

Colden M, Dar AA, Saini S, Dahiya PV, Shahryari V, Yamamura S, Tanaka Y, Stein G, Dahiya R, Majid S. 

Cell Death Dis. 2017 Jan 26;8(1):e2572. doi: 10.1038/cddis.2017.15. PMID: 28125091 Free PMC article. 

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MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer

Bucay N, Sekhon K, Yang T, Majid S, Shahryari V, Hsieh C, Mitsui Y, Deng G, Tabatabai ZL, Yamamura S, Calin GA, Dahiya R, Tanaka Y, Saini S.
Oncogene. 2017 May 11;36(19):2667-2679. doi: 10.1038/onc.2016.419. Epub 2016 Nov 28.PMID: 27893706 Free PMC article.
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Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N, Dahiya R.
Cancer Res. 2015 Apr 1;75(7):1322-31. doi: 10.1158/0008-5472.CAN-14-2931. Epub 2015 Jan 19.PMID: 25600645 Free PMC article.
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CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma

Mitsui Y, Chang I, Fukuhara S, Hiraki M, Arichi N, Yasumoto H, Hirata H, Yamamura S, Shahryari V, Deng G, Wong DK, Majid S, Shiina H, Dahiya R, Tanaka Y.
BMC Cancer. 2015 Dec 1;15:942. doi: 10.1186/s12885-015-1951-0.PMID: 26626260 Free PMC article.
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Restoration of insulin-like growth factor binding protein-related protein 1 has a tumor-suppressive activity through induction of apoptosis in human prostate cancer

Mutaguchi K, Yasumoto H, Mita K, Matsubara A, Shiina H, Igawa M, Dahiya R, Usui T.

Cancer Res. 2003 Nov 15;63(22):7717-23.PMID: 14633696 Free article.

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Regulation of SRC kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N, Dahiya R.

Saini S, Majid S, Shahryari V, Tabatabai ZL, Arora S, Yamamura S, Tanaka Y, Dahiya R, Deng G. Mol Cancer Ther. 2014 Jul;13(7):1952-63. doi: 10.1158/1535-7163.MCT-14-0017. Epub 2014 May 9.PMID: 24817628 Free PMC article.

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Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells

Hirata H, Hinoda Y, Shahryari V, Deng G, Tanaka Y, Tabatabai ZL, Dahiya R.
Br J Cancer. 2014 Mar 18;110(6):1645-54. doi: 10.1038/bjc.2014.48. Epub 2014 Feb 6.PMID: 24504368 Free PMC article.
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Frizzled homolog proteins, microRNAs and Wnt signaling in cancer

Ueno K, Hirata H, Hinoda Y, Dahiya R.

Int J Cancer. 2013 Apr 15;132(8):1731-40. doi: 10.1002/ijc.27746. Epub 2012 Aug 30.PMID: 22833265 Free PMC article. Review.

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Possible involvement of Wnt11 in colorectal cancer progression

Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, Dahiya R, Hinoda Y.

Mol Carcinog. 2013 Mar;52(3):207-17. doi: 10.1002/mc.21845. Epub 2011 Dec 7.PMID: 22161723

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Genistein downregulates onco-miR-1260b and inhibits Wnt-signalling in renal cancer cells

Hirata H, Ueno K, Nakajima K, Tabatabai ZL, Hinoda Y, Ishii N, Dahiya R.

Br J Cancer. 2013 May 28;108(10):2070-8. doi: 10.1038/bjc.2013.173. Epub 2013 Apr 16.PMID: 23591200 Free PMC article.

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Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells

Chang I, Majid S, Saini S, Zaman MS, Yamamura S, Chiyomaru T, Shahryari V, Fukuhara S, Deng G, Dahiya R, Tanaka Y.

Mol Cancer Ther. 2013 Jun;12(6):1049-59. doi: 10.1158/1535-7163.MCT-12-1187. Epub 2013 Apr 11.PMID: 23580416 Free article.

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microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer

Ueno K, Hirata H, Shahryari V, Deng G, Tanaka Y, Tabatabai ZL, Hinoda Y, Dahiya R.

Br J Cancer. 2013 Apr 30;108(8):1659-67. doi: 10.1038/bjc.2013.125. Epub 2013 Mar 28.PMID: 23538390 Free PMC article.

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miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways

Majid S, Dar AA, Saini S, Shahryari V, Arora S, Zaman MS, Chang I, Yamamura S, Tanaka Y, Chiyomaru T, Deng G, Dahiya R.

Clin Cancer Res. 2013 Jan 1;19(1):73-84. doi: 10.1158/1078-0432.CCR-12-2952. Epub 2012 Nov 12.PMID: 23147995 Free PMC article.

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miRNA-708 control of CD44(+) prostate cancer-initiating cells

Saini S, Majid S, Shahryari V, Arora S, Yamamura S, Chang I, Zaman MS, Deng G, Tanaka Y, Dahiya R.

Cancer Res. 2012 Jul 15;72(14):3618-30. doi: 10.1158/0008-5472.CAN-12-0540. Epub 2012 May 2.PMID: 22552290 Free article.

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MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma

Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Chang I, Tanaka Y, Gupta A, Dahiya R.

Carcinogenesis. 2012 Feb;33(2):294-300. doi: 10.1093/carcin/bgr286. Epub 2011 Dec 9.PMID: 22159222 Free PMC article.

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miRNA-34b inhibits prostate cancer through demethylation, active chromatin modifications, and AKT pathways

Majid S, Dar AA, Saini S, Shahryari V, Arora S, Zaman MS, Chang I, Yamamura S, Tanaka Y, Chiyomaru T, Deng G, Dahiya R.

Clin Cancer Res. 2013 Jan 1;19(1):73-84. doi: 10.1158/1078-0432.CCR-12-2952. Epub 2012 Nov 12.PMID: 23147995 Free PMC article.

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Functional significance of Wnt inhibitory factor-1 gene in kidney cancer

Kawakami K, Hirata H, Yamamura S, Kikuno N, Saini S, Majid S, Tanaka Y, Kawamoto K, Enokida H, Nakagawa M, Dahiya R.

Cancer Res. 2009 Nov 15;69(22):8603-10. doi: 10.1158/0008-5472.CAN-09-2534. Epub 2009 Nov 3.PMID: 19887605 Free article.

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MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer

Hirata H, Hinoda Y, Ueno K, Shahryari V, Tabatabai ZL, Dahiya R.

Carcinogenesis. 2012 Jan;33(1):41-8. doi: 10.1093/carcin/bgr239. Epub 2011 Nov 1.PMID: 22049531 Free PMC article.

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Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway

Chang I, Liu J, Majid S, Saini S, Zaman MS, Yamamura S, Shahryari V, Chiyomaru T, Deng G, Dahiya R, Tanaka Y.

Carcinogenesis. 2012 Feb;33(2):420-6. doi: 10.1093/carcin/bgr294. Epub 2011 Dec 9.PMID: 22159223

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Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4

Ueno K, Hirata H, Majid S, Yamamura S, Shahryari V, Tabatabai ZL, Hinoda Y, Dahiya R.

Mol Cancer Ther. 2012 Jan;11(1):244-53. doi: 10.1158/1535-7163.MCT-11-0592. Epub 2011 Nov 4.PMID: 22057916 Free PMC article.

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miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer

Majid S, Dar AA, Saini S, Arora S, Shahryari V, Zaman MS, Chang I, Yamamura S, Tanaka Y, Deng G, Dahiya R.

Cancer Res. 2012 Dec 15;72(24):6435-46. doi: 10.1158/0008-5472.CAN-12-2181. Epub 2012 Oct 16.PMID: 23074286 Free PMC article.

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Small dsRNAs induce transcriptional activation in human cells

Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, Enokida H, Dahiya R.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17337-42. doi: 10.1073/pnas.0607015103. Epub 2006 Nov 3.PMID: 17085592 Free PMC article.

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MicroRNA-373 induces expression of genes with complementary promoter sequences

Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13. doi: 10.1073/pnas.0707594105. Epub 2008 Jan 28.PMID: 18227514 Free PMC article.

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Epigenetic changes in prostate cancer: implication for diagnosis and treatment

Li LC, Carroll PR, Dahiya R.

J Natl Cancer Inst. 2005 Jan 19;97(2):103-15. doi: 10.1093/jnci/dji010.PMID: 15657340 Review.

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Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer

Sasaki M, Kotcherguina L, Dharia A, Fujimoto S, Dahiya R.

Cancer Res. 2001 Apr 15;61(8):3262-6.PMID: 11309276 Free article.

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Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression

Li LC, Chui R, Nakajima K, Oh BR, Au HC, Dahiya R.

Cancer Res. 2000 Feb 1;60(3):702-6.PMID: 10676656 Free article.

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CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility

Hirata H, Hinoda Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Rabban JT, Chen LM, Dahiya R.

Cancer. 2008 May 1;112(9):1964-73. doi: 10.1002/cncr.23392.PMID: 18318428 Free article.

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Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer

Tanaka Y, Sasaki M, Shiina H, Tokizane T, Deguchi M, Hirata H, Hinoda Y, Okayama N, Suehiro Y, Urakami S, Kawakami T, Kaneuchi M, Pookot D, Igawa M, Okuyama A, Ishii N, Dahiya R.

Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):238-44. doi: 10.1158/1055-9965.EPI-05-0550.PMID: 16492910 Free article.

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Multigene methylation analysis for detection and staging of prostate cancer

Enokida H, Shiina H, Urakami S, Igawa M, Ogishima T, Li LC, Kawahara M, Nakagawa M, Kane CJ, Carroll PR, Dahiya R.

Clin Cancer Res. 2005 Sep 15;11(18):6582-8. doi: 10.1158/1078-0432.CCR-05-0658.PMID: 16166436 Free article.

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Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer

Tokizane T, Shiina H, Igawa M, Enokida H, Urakami S, Kawakami T, Ogishima T, Okino ST, Li LC, Tanaka Y, Nonomura N, Okuyama A, Dahiya R.

Clin Cancer Res. 2005 Aug 15;11(16):5793-801. doi: 10.1158/1078-0432.CCR-04-2545.PMID: 16115918 Free article.

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Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer

Majid S, Dar AA, Saini S, Chen Y, Shahryari V, Liu J, Zaman MS, Hirata H, Yamamura S, Ueno K, Tanaka Y, Dahiya R.

Cancer Res. 2010 Apr 1;70(7):2809-18. doi: 10.1158/0008-5472.CAN-09-4176. Epub 2010 Mar 23.PMID: 20332239 Free article.

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MicroRNAs 221/222 and genistein-mediated regulation of ARHI tumor suppressor gene in prostate cancer

Chen Y, Zaman MS, Deng G, Majid S, Saini S, Liu J, Tanaka Y, Dahiya R.

Cancer Prev Res (Phila). 2011 Jan;4(1):76-86. doi: 10.1158/1940-6207.CAPR-10-0167. Epub 2010 Nov 11.PMID: 21071579 Free PMC article.

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Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer

Ogishima T, Shiina H, Breault JE, Terashima M, Honda S, Enokida H, Urakami S, Tokizane T, Kawakami T, Ribeiro-Filho LA, Fujime M, Kane CJ, Carroll PR, Igawa M, Dahiya R. 

Oncogene. 2005 Oct 13;24(45):6765-72. doi: 10.1038/sj.onc.1208811. PMID: 16007175

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Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl) nitrosamine-induced murine bladder cancer

Shiina H, Igawa M, Urakami S, Shigeno K, Yoneda T, Terashima M, Deguchi M, Ribeiro-Filho L, Dahiya R.

Cancer Res. 2001 Oct 1;61(19):7101-9.PMID: 11585741 Free article.

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Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer

Shiina H, Breault JE, Basset WW, Enokida H, Urakami S, Li LC, Okino ST, Deguchi M, Kaneuchi M, Terashima M, Yoneda T, Shigeno K, Carroll PR, Igawa M, Dahiya R.

Cancer Res. 2005 Mar 15;65(6):2130-8. doi: 10.1158/0008-5472.CAN-04-3398.PMID: 15781623 Free article.

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CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer

Enokida H, Shiina H, Igawa M, Ogishima T, Kawakami T, Bassett WW, Anast JW, Li LC, Urakami S, Terashima M, Verma M, Kawahara M, Nakagawa M, Kane CJ, Carroll PR, Dahiya R.

Cancer Res. 2004 Sep 1;64(17):5956-62. doi: 10.1158/0008-5472.CAN-04-0081.PMID: 15342374 Free article.

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Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer

Sasaki M, Kaneuchi M, Sakuragi N, Dahiya R.

Cancer Res. 2003 Jun 15;63(12):3101-6.PMID: 12810635 Free article.

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ABH blood group antigen expression, synthesis, and degradation in human colonic adenocarcinoma cell lines

Dahiya R, Itzkowitz SH, Byrd JC, Kim YS.

Cancer Res. 1989 Aug 15;49(16):4550-6.

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Methylation and inactivation of estrogen, progesterone, and androgen receptors in prostate cancer

Sasaki M, Tanaka Y, Perinchery G, Dharia A, Kotcherguina I, Fujimoto Si, Dahiya R.

J Natl Cancer Inst. 2002 Mar 6;94(5):384-90. doi: 10.1093/jnci/94.5.384. PMID: 11880477

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Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer

Ogishima T, Shiina H, Breault JE, Tabatabai L, Bassett WW, Enokida H, Li LC, Kawakami T, Urakami S, Ribeiro-Filho LA, Terashima M, Fujime M, Igawa M, Dahiya R.

Clin Cancer Res. 2005 Feb 1;11(3):1028-36.PMID: 15709168 Free article.

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