Patents by Inventor Rajvir Dahiya

Rajvir Dahiya has several patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Method of multivariate molecule analysis

Patent number: 10822661

Abstract: A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods find use in avoidance or postponement of surgical removal of cancer tissue.

Type: Grant

Filed: September 3, 2015

Date of Patent: November 3, 2020

Assignee: MIODx

Inventors: Rajvir Dahiya, M. Allen Northrup

Method of analysis allowing avoidance of surgery

Patent number: 10801072 

Abstract: A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods allow avoidance of surgery to remove cancerous tissue. 

Type: Grant 

Filed: September 3, 2015 

Date of Patent: October 13, 2020 

Assignee: MIODx 

Inventors: Rajvir Dahiya, M. Allen Northrup 

Method of analysis allowing avoidance of surgery

Publication number: 20170275702 

Abstract: A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods allow avoidance of surgery to remove cancerous tissue. 

Type: Application 

Filed: September 3, 2015 

Publication date: September 28, 2017 

Applicant: MIODx 

Inventors: Rajvir DAHIYA, M. Allen NORTHRUP

Method of multivariate molecule analysis

Publication number: 20170233825 

Abstract: A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods find use in avoidance or postponement of surgical removal of cancer tissue. 

Type: Application 

Filed: September 3, 2015 

Publication date: August 17, 2017 

Applicant: MIODx 

Inventors: Rajvir DAHIYA, M. Allen NORTHRUP 

Method of multivariate molecule analysis

Patent number: 10822661

Abstract: A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) DNA methylation of tumor suppressor genes; (c) non-coding RNA expression (microRNA profiling); and (d) long non-coding RNA expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary. The assay methods find use in avoidance or postponement of surgical removal of cancer tissue.

Type: Grant

Filed: September 3, 2015

Date of Patent: November 3, 2020

Assignee: MIODx

Inventors: Rajvir Dahiya, M. Allen Northrup

Small activating RNA molecules and methods of use

Patent number: 9297008 

Abstract: The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. 

Type: Grant 

Filed: October 1, 2014 

Date of Patent: March 29, 2016 

Assignee: The Regents of the University of California 

Inventors: Longcheng Li, Rajvir Dahiya 

Small Activating RNA Molecules and Methods of Use

Publication number: 20150104869 

Abstract: The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. 

Type: Application 

Filed: October 1, 2014 

Publication date: April 16, 2015 

Inventors: Longcheng Li, Rajvir Dahiya

Small activating RNA molecules and methods of use

Patent number: 8877721 

Abstract: The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. 

Type: Grant 

Filed: April 11, 2006 

Date of Patent: November 4, 2014 

Assignee: The Regents of the University of California 

Inventors: Longcheng Li, Rajvir Dahiya 

Methods and Compositions for Increasing Gene Expression

Publication number: 20110054012 

Abstract: The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a microRNA (miRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. 

Type: Application 

Filed: December 23, 2008 

Publication date: March 3, 2011 

Inventors: Robert F. Place, Long-Cheng Li, Rajvir Dahiya 

Small Activating RNA Molecules and Methods of Use

Publication number: 20100210707 

Abstract: The present invention provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a non-coding nucleic acid sequence of the gene. 

Type: Application 

Filed: April 11, 2006 

Publication date: August 19, 2010 

Inventors: Longcheng Li, Rajvir Dahiya 

Acellular matrix grafts of collagen and elastic fiber

Patent number: 7306627 

Abstract: Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues. 

Type: Grant 

Filed: January 18, 2002 

Date of Patent: December 11, 2007 

Assignee: The Regents of the University of California 

Inventors: Emil A. Tanagho, Rajvir Dahiya, Tom F. Lue, Gerald R. Cunha 

Acellular matrix grafts: preparation and use

Publication number: 20020128711 

Abstract: Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues. 

Type: Application 

Filed: January 18, 2002 

Publication date: September 12, 2002 

Applicant: The Regents of the University of California 

Inventors: Emil A. Tanagho, Rajvir Dahiya, Tom F. Lue, Gerald R. Cunha 

Acellular matrix grafts: preparation and use

Patent number: 6371992 

Abstract: Acellular matrix grafts are provided with are isolated from natural sources and consist essentially of a collagen and elastin matrix which is devoid of cellular components. The grafts are useful scaffolds which promote the regeneration of muscle tissue and aid in restoring muscle function. Due to their acellular nature, the grafts lack antigenicity. As a result, the acellular matrix grafts can be isolated from autographic, allographic or xenographic tissues. 

Type: Grant 

Filed: December 19, 1997 

Date of Patent: April 16, 2002 

Assignee: The Regents of the University of California 

Inventors: Emil A. Tanagho, Rajvir Dahiya, Tom F. Lue, Gerald R. Cunha

Smooth muscle tissue formation in vivo using cultured smooth muscle cells combined with an extracellular matrix

Patent number: 5656478 

Abstract: The present invention provides a method of growing smooth muscle cells in a host with the purpose of maintaining natural cellular function by the function of smooth muscle tissue. In this method, smooth muscle cells are freed from isolated smooth muscle tissue then cultured and injected into the host in combination with an extracellular matrix. 

Type: Grant 

Filed: February 25, 1994 

Date of Patent: August 12, 1997 

Assignee: The Regents of the University of California 

Inventors: Emil A. Tanagho, Rajvir Dahiya, Tom F. Lue, Gerald R. Cunha 

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